Frontiers in Lipidomics

Abstract Title: The use of ion mobility coupled with high resolution mass spectrometry to improve separation and identification of lipid biomarkers in metabolic diseases

Tuesday 15:30 - 16:00

My programme of research focuses on the development of metabolomics and lipidomics tools to investigate aspects of the Metabolic Syndrome. In particular I have an interest in identifying biomarkers that stratify patients according to risk factor of metabolic diseases and understand the associated underlying mechanisms. My group has been at the centre of the development of metabolomics as a research tool in biochemistry, and in particular its application to medical diagnostics. Since my fellowship in the Nicholson group at Imperial College London, my group at the University of Cambridge has examined the use of metabolomics as a tool for monitoring atherosclerosis [Kirschenlohr et al., Nature Medicine, 2006; Cheng et al., Physiol Genomics, 2010], modelling metabolism changes in cardiac disease [Wang et al., J Prot Res, 2015] and modelling whole body metabolism in aspects of the Metabolic Syndrome [Roberts et al, Genome Biol. 2011; Roberts et al., Diabetes, 2015, 2017; Atherton et al., Mol Syst Biol. 2009]. Central to the ethos of the group is a mechanistic understanding of why these metabolic changes occur. I am Professor of Metabolism and Nutrition at the University of Cambridge, an Honorary Professor at Imperial College London and a Visiting Professor at the University of Cagliari, Italy. I am also the recipient of a Thought Leader Award in mass spectrometry from Agilent Corporation. I am the current President of the Metabolomics Society and a director of the Metabolic Profiling Forum.